Which cancer type has a strong association with eosinophil infiltration?

Mast cell tumors have a particularly strong association with eosinophil infiltration. This is largely due to the release of mediators such as histamine and other cytokines from the mast cells themselves. Eosinophils are often recruited to inflammatory sites, particularly in the presence of mast cell activation. The relationship is significant because mast cell tumors can lead to a local tissue environment that attracts eosinophils, which are known for their role in responding to allergic reactions and parasitic infections, but also in some neoplastic processes.

In the case of mast cell tumors, the infiltration of eosinophils can be observed in the tumor microenvironment, making their presence a noteworthy histopathological finding. This infiltration can also influence the clinical behavior of the tumor and the associated inflammatory response, thereby offering insights into the aggressiveness of the tumor and potential treatment strategies.