What sampling method is commonly used for cytological analysis?

Fine-needle aspiration is widely recognized as the standard method for obtaining samples for cytological analysis. This technique involves using a thin, hollow needle to extract cells from tumors or lesions. It is favored because it is minimally invasive, causes less discomfort for the animal, and can often be performed quickly in an outpatient setting. The cells obtained can be rapidly processed and stained, allowing for immediate evaluation under a microscope, making it especially useful for diagnosing conditions like tumors, infections, or inflammation.

This method enables the acquisition of a sufficient quantity of cells for analysis while preserving the cellular architecture to some extent, which aids pathologists in determining the nature of the lesion. In contrast, other methods like core biopsies and excisional biopsies entail more extensive procedures and usually require sedation or anesthesia, making them less practical for quick diagnostics. Scrape biopsies, while useful in certain situations, typically do not yield as comprehensive a cellular sample as fine-needle aspiration, particularly for deeper lesions.