What is a notable paraneoplastic syndrome related to lymphoma?

Hypercalcemia is a notable paraneoplastic syndrome associated with lymphoma, particularly in certain types of lymphoid neoplasms. In the context of cancers, paraneoplastic syndromes arise from the systemic effects of tumors, which can lead to a variety of metabolic disturbances. In lymphomas, hypercalcemia often occurs due to the secretion of parathyroid hormone-related peptide (PTHrP) or other factors that mimic parathyroid hormone, leading to increased calcium release from bones and heightened renal tubular reabsorption of calcium.

Lymphoma's capacity to induce hypercalcemia is significant for diagnosis and treatment planning, as managing hypercalcemia can be a critical aspect of therapy in affected animals. Recognizing this paraneoplastic syndrome is crucial because it can reflect the progression or severity of the underlying neoplastic process and may require specific medical intervention to address the metabolic abnormalities caused by the tumor.