What clinical finding is often associated with epitheliotrophic T-cell lymphoma?

Epitheliotrophic T-cell lymphoma, also known as cutaneous T-cell lymphoma, is a type of lymphoma that particularly targets the skin and is characterized by an infiltration of neoplastic T-cells in the epithelial structures. One of the notable clinical findings associated with this form of lymphoma is the development of a paraneoplastic syndrome related to hypercalcemia.

In this context, hypercalcemia arises due to the production of parathyroid hormone-related peptide (PTHrP) by the neoplastic T-cells. This peptide mimics the action of parathyroid hormone, leading to increased calcium mobilization from bones, enhanced renal tubular reabsorption of calcium, and increased intestinal absorption of calcium. As a result, hypercalcemia can cause various clinical signs such as lethargy, weakness, and gastrointestinal disturbances, making it a significant finding in patients with epitheliotrophic T-cell lymphoma.

This association with hypercalcemia through a paraneoplastic syndrome underscores the importance of recognizing systemic effects of neoplasms, as they can significantly impact the clinical picture and guide diagnostic and therapeutic approaches. Understanding this connection is crucial for veterinarians when diagnosing and managing cases of lymphoma in small animals.